Ka/Ks ratio

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Ka/Ks ratio

The Ka/Ks ratio (pronounced as "ka over ks ratio"), also known as the nonsynonymous/synonymous substitution ratio, is a measure used in molecular evolution to estimate the balance between neutral mutations, purifying selection, and beneficial mutations.

Pronunciation

  • Ka/Ks ratio: /kɑː ˈoʊvər keɪs ˈreɪʃioʊ/

Etymology

The term "Ka/Ks ratio" is derived from the symbols Ka and Ks, which represent nonsynonymous and synonymous substitutions, respectively, in the context of genetic mutation and molecular evolution.

Definition

The Ka/Ks ratio is a measure in genetics that compares the rate of nonsynonymous substitutions (Ka) to the rate of synonymous substitutions (Ks) in protein-coding DNA sequences. This ratio is used to infer the type of natural selection acting on a protein-coding gene. A Ka/Ks ratio greater than 1 indicates positive or adaptive selection, a ratio less than 1 suggests purifying selection, and a ratio of 1 suggests neutral evolution.

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