Kisspeptin

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Kisspeptin

Kisspeptin (pronounced: kis-pep-tin), also known as metastin, is a protein that in humans is encoded by the KISS1 gene.

Etymology

The name "kisspeptin" is derived from the Hershey's Kisses chocolate, as the gene was discovered in Hershey, Pennsylvania.

Function

Kisspeptin is a potent stimulator of gonadotropin-releasing hormone (GnRH) secretion and is essential for fertility. It plays a key role in the regulation of the hypothalamic-pituitary-gonadal axis, which controls sexual maturation and fertility.

Clinical significance

Mutations in the KISS1 gene have been associated with hypogonadotropic hypogonadism, a condition characterized by delayed or absent puberty and infertility.

Related terms

See also

External links

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