Kleine–Levin syndrome

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Kleine–Levin syndrome
Other namesFamilial hibernation syndrome [1]
SpecialtyLua error in Module:WikidataIB at line 721: attempt to index field 'wikibase' (a nil value).

Kleine–Levin syndrome (KLS), is a rare sleep disorder characterized by persistent episodic hypersomnia and cognitive or mood changes. Many patients also experience hyperphagia, hypersexuality and other symptoms. Patients generally experience recurrent episodes of the condition for more than a decade and may return at a later age. Individual episodes generally last more than a week, sometimes lasting for months. The condition greatly affects the personal, professional, and social lives of sufferers. The severity of symptoms and the course of the syndrome vary between sufferers. Patients commonly have about 20 episodes over about a decade. Several months generally elapse between episodes. The onset of the condition usually follows a viral infection; several different viruses have been observed to trigger KLS. It is generally only diagnosed after similar conditions have been excluded; MRI, CT scans, lumbar puncture, and toxicology tests are used to rule out other possibilities. The syndrome's mechanism is not known, but the thalamus is thought to possibly play a role. SPECT has shown thalamic hypoperfusion of patients during episodes.

KLS is very rare, occurring at a rate of one in 1 million, which limits research into genetic factors. The condition primarily affects adolescent males, though females can also be affected and the age of onset varies. There is no known cure, and there is little evidence supporting drug treatment. Lithium has been reported to have limited effects in case reports, decreasing the length of episodes and duration between them in some patients[2]. Stimulants have been shown to promote wakefulness during episodes, but they do not counteract cognitive symptoms or decrease the duration of episodes. The condition is named after Willi Kleine and Max Levin[3], who described cases of the disease in the early 20th century. It was added to the International Classification of Sleep Disorders in 1990.


Patients with Kleine–Levin syndrome (KLS) experience recurring episodes of prolonged sleep (hypersomnia).[4] In most cases, patients sleep 15 to 21 hours a day during episodes.Template:Sfn Excessive appetite (hyperphagia) and unusual cravings are present in half to two thirds of cases.Template:SfnTemplate:SfnTemplate:Sfn About half of patients, mainly male patients, experience dramatically increased sexual urges (hypersexuality).Template:SfnTemplate:Sfn Several other symptoms usually accompany the syndrome, including marked changes in mood and cognitive ability.[4] Derealization and severe apathy are present in at least 80 percent of cases.Template:Sfn About one third of patients experience hallucinations or delusions.Template:Sfn Depression and anxiety occur less commonly; one study found them in about 25 percent of patients.Template:Sfn Individuals usually cannot remember what happened during episodes.Template:Sfn Repetitive behaviors and headaches are commonly reported.Template:Sfn Some patients act very childlike during episodes,Template:Sfn and communication skills and coordination sometimes suffer.Template:Sfn

Sleep studies of KLS show varying results based on the amount of time the patient is observed. Slow wave sleep is often reduced at the beginning of episodes, and REM sleep is reduced near the end.Template:Sfn Conversely, REM sleep is often normal at the beginning, and slow wave sleep is often normal by the conclusion.Template:Sfn Stage two non-rapid eye movement sleep is often interrupted during KLS. Studies also show that stage one and three non-rapid eye movement sleep become more efficient when the episodes end.Template:Sfn The Multiple Sleep Latency Test has yielded inconsistent results when given to KLS patients.Template:Sfn In many cases, hours are spent in a withdrawn sleep-like state while awake during episodes.Template:Sfn Most sleep studies have been performed while subject is near the end of their episodes.Template:Sfn Some patients experience brief insomnia and become very happy and talkative after the episode ends.Template:Sfn

The first time a patient experiences KLS, it usually occurs along with symptoms that are similar to those of the flu or encephalitis. In at least 75 percent of cases, symptoms occur after an airway infection or a fever. Viruses observed before the development of the condition include Epstein-Barr virus, varicella zoster virus, herpes zoster virus, Influenza A virus subtypes, and adenovirus. Several days after symptoms first occur, patients become very tired.Template:Sfn In cases that occur after an infection, KLS usually starts within three to five days for teenagers and fewer for children.Template:Sfn In other cases, alcohol consumption, head injury, or international travel precede symptoms.Template:SfnTemplate:Sfn Lifestyle habits, such as stress, alcohol abuse and lack of sleep and stress, have also been proposed as possible triggers.[4] First episodes of KLS are preceded by a clear event in about 90 percent of cases.Template:Sfn Recurrences generally do not have clear triggers; only about 15 percent have a precipitating event.Template:Sfn

The condition generally disrupts the social lives and academic or professional obligations of sufferers.[4]Template:Sfn Some patients also gain weight during episodes.Template:Sfn The most severe cases cause a long-term impact on mood and cognitive attention.Template:Sfn In rare cases, patients experience long-term memory problems.Template:Sfn

In patients with KLS, MRI and CT scans show normal brain morphology. When SPECT is performed, hypoperfusion can often be observed in the brain,Template:Sfn particularly in the thalamic and frontotemporal areas.Template:Sfn The hypoperfusion is significantly diminished between episodes.Template:Sfn Serum biology, c-reactive proteins and leptins, the hormonal pituitary axis, and protein in the cerebral spinal fluid (CSF) are normal in KLS patients.Template:Sfn


It is not known what causes KLS, but several mechanisms have been proposed. One possible explanation is hypothalamic or circadian dysfunction.[4] The thalamus probably plays a role in the out-of-control sleeping,Template:Sfn and patients with diencephalic–hypothalamic dysfunction caused by tumors experience symptoms similar to those of KLS patients.[4] Specifically, the medial temporal regions of the thalamus may be involved,Template:Sfn although examinations of KLS patients have not consistently found abnormalities in this area.Template:Sfn The temporal lobe also appears to play a role in the condition, possibly causing cognitive difficulties. The apathy and disinhibition found in some KLS sufferers suggest that the condition may include frontal lobe dysfunction as well. The involvement of the thalamus, temporal lobe, and frontal lobe of the brain suggests that there is a multifocal, localized encephalopathy. There are also persistent subclinical abnormalities in KLS sufferers.Template:Sfn

Another possible explanation concerns the metabolism of serotonin and dopamine. An imbalance in the neurotransmitter pathways of these chemicals could play a role.[4] Viral infections have also been suggested as a possible cause. Evidence for their role includes lesions found in autopsies.[4] CSF samples from KLS patients indicate that the condition has a different cause than influenza-associated encephalopathy.Template:Sfn Triggers of KLS may also affect the blood-brain barrier, which could play a role in the condition.Template:Sfn There is limited evidence of what role hypocretin may play, although it often influences hypersomnia.Template:Sfn

Androgen might (indirectly) block melatonin receptors, possibly by mean of vasodilation, and cause cholinergic abnormalities in some cases of Kleine–Levin syndrome.Template:Sfn

Because KLS occurs at a much higher rate in Jews and in some families, it is likely that there is some genetic component in addition to environmental factors.Template:Sfn Genetic studies hold promise for understanding the disease, but they have yielded inconsistent resultsTemplate:Sfn and few patients are available for testing.Template:Sfn

Epilepsy and depression do not appear to cause KLS. The condition's rapid onset after infections indicates that the immune system is not to blame.Template:Sfn

One study has suggested a link to the gene LMOD3 on chromosome 3.[5]


KLS can be diagnosed when there is confusion, apathy, or derealization in addition to frequent bouts of extreme tiredness and prolonged sleep.Template:Sfn The earliest it can be diagnosed is the second episode, this is not common.Template:Sfn The condition is generally treated as a diagnosis of exclusion.Template:Sfn Because KLS is rare, other conditions with similar symptoms are usually considered first.Template:Sfn

MRIs can determine if the symptoms are caused by certain brain disorders, stroke, and multiple sclerosis. Lumbar puncture can determine if encephalitis is the cause. KLS must be differentiated from substance abuse by toxicology tests.Template:Sfn The use of Electroencephalography (EEG) can exclude temporal status epilepticus from consideration. EEGs are normal in about 70% of KLS patients, but background slowing may sometimes be detected.Template:SfnTemplate:Sfn In addition, low-frequency high-amplitude waves can be observed during waking hours.Template:Sfn

Initially, KLS appears similar to bipolar depression.Template:Sfn Patients with frontal-lobe syndromes and Klüver-Bucy syndrome also display similar symptoms, but these conditions can be differentiated by the presence of brain lesions.Template:Sfn KLS should also be distinguished from very rare cases of menstruation-caused hypersomnia.Template:Sfn


Lithium is the only drug that appears to have a preventive effect. In two studies of more than 100 patients, lithium helped prevent recurrence of symptoms in 20% to 40% of cases. The recommended blood level of lithium for KLS patients is 0.8-1.2 mEq/ml. It is not known if other mood stabilizers have an effect on the condition.Template:Sfn Anti-depressants do not prevent recurrence.[4]


Several drug therapies have been used on patients with KLS, but none of them have been subject to randomized controlled trials. A 2016 Cochrane Review concluded that "No evidence indicates that pharmacological treatment for Kleine-Levin syndrome is effective and safe".[4]

In several cases, stimulants, including modafinil,Template:Sfn have been reported to have a limited effect on patients, often alleviating sleepiness.[4] They can cause behavioral problems,Template:Sfn but they may pose fewer issues if used in older patients with mild symptoms.Template:Sfn In some case reports, lithium has been reported to decrease the length of episodes and the severity of their symptoms and to increase the time between episodes.[4] It has been reported to be effective in about 25 to 60 percent of cases. Its use carries the risk of side effects in the thyroid or kidneys. Anti-psychotics and benzodiazepines can help alleviate psychotic and anxiety related symptoms, respectively.Template:Sfn Carbamazepine has been reported to be less effective than lithium but more effective than some drugs in its class.Template:Sfn Electroconvulsive therapy is not effective and worsens symptoms.Template:Sfn

KLS patients generally do not need to be admitted to hospitals. It is recommended that caregivers reassure them and encourage them to maintain sleep hygiene.Template:Sfn It may also be necessary for patients to be prevented from putting themselves in dangerous situations, such as driving.Template:Sfn


The frequency of KLS episodes can vary from attacks one week in length occurring twice a year to dozens of episodes that follow each other in close succession.Template:Sfn The median duration of KLS episodes is about ten days, but some last several weeks or months. A study of 108 patients found an average of 19 episodes over the duration of the disease.Template:Sfn Another study found a median of 3.5 months between episodes.Template:Sfn Outside of episodes, there is no disturbance in patients' sleep patterns and they are generally asymptomatic.Template:SfnTemplate:Sfn Patients do not experience the same symptoms in each episode.Template:Sfn

About 80 percent of patients are adolescents when they first experience KLS. On some occasions though, its first occurrence comes in childhood or adulthood.Template:Sfn In most adolescent-onset patients, symptoms cease by the time they are 30 years old. A French study of 108 patients found a median duration of 13 years,Template:Sfn but a review of 186 cases found a median duration of 8 years.Template:Sfn Unusually young or old patients and those who experience hypersexuality tend to have a more severe course. Patients who initially have frequent attacks generally see the disease cease earlier than others.Template:Sfn The condition spontaneously resolves,Template:Sfn and the patient is considered to be cured if there have been no symptoms for six years.Template:Sfn


Population-based studies of KLS have not been performed. Its prevalence is about 1 case per million people.Template:Sfn In France, KLS has a prevalence of 1.5 per million people. It occurs most frequently among Jews in the US and Israel. First-degree relatives of people who have suffered from the syndrome are much more likely than the general population to suffer from it, although only in about one percent of cases do family members contract it. About 70 to 90 percent of patients are male. Patients with the syndrome are more likely than the general population to have genetic disorders, and about a third of people with the syndrome encountered some form of birth difficulty.Template:Sfn In a study of 186 older patients, about ten percent had preexisting psychiatric issues.Template:Sfn One study found that about ten percent of patients had a neurological condition before KLS developed.Template:Sfn The condition does not appear to occur most frequently in one season.Template:Sfn


In 1815, there was a report of a young man who showed excessive appetite and prolonged sleep after experiencing a fever; this may have been an early description of the condition.Template:Sfn Another case with similar symptoms was described by Brierre de Boismont in 1862.Template:Sfn

Five patients with symptoms of persistent sleepiness were described in detail in 1925 by Willi Kleine, a neurologist from Frankfurt. This report was followed four years later by details of a similar case by New York-based psychiatrist Max Levin. In 1935, Levin published information about several more cases, including one described by Kleine. Levin noted that some patients displayed an intense appetite in addition to their persistent tiredness. MacDonald Critchley, who first wrote about the condition in 1942,Template:Sfn described 11 cases he had examined and reviewed 15 other published cases in a 1962 publication. In the report, which included patients he had examined in the Royal Navy during World War II,Template:Sfn he observed that irritability and depersonalization often occurred while patients were awake. He named the condition Kleine–Levin syndrome and noted four common traits: hypersexuality, adolescent onset, spontaneous resolution, and compulsive eating.Template:Sfn He believed that the condition only affected males, but later studies showed some female patients.Template:Sfn In the 1970s, several psychoanalytic and psychodynamic explanations for the condition were proposed.Template:Sfn In 1980, a Hawaiian–Caucasian family was found in which nine family members suffered from the condition.Template:Sfn

Diagnostic criteria for KLS was established by Schmidt in 1990, and the International Classification of Sleep Disorders further refined them.[4] KLS is classified as a sleep disorder,Template:Sfn specifically one of recurrent hypersomnia.Template:Sfn Before 2005, hyperphagia and hypersexuality were thought to occur in all cases. That was changed with the guidelines published that year, which noted that they did not always occur.Template:Sfn


  1. "Kleine Levin syndrome | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program". rarediseases.info.nih.gov. Retrieved 21 March 2019.
  2. Poppe, M, Friebel, D, Reuner, U, Todt, H, Koch, R, and Heubner, G. The Kleine-Levin syndrome - effects of treatment with lithium. Neuropediatrics 2003;34:113-9
  3. Levin, M. (1936). Periodic somnolence and morbid hunger: a new syndrome. Brain, 59(4), 494-504.
  4. 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 de Oliveira, Marcio M.; Conti, Cristiane; Prado, Gilmar F. (2016-05-06). "Pharmacological treatment for Kleine-Levin syndrome". The Cochrane Database of Systematic Reviews (5): CD006685. doi:10.1002/14651858.CD006685.pub4. ISSN 1469-493X. PMID 27153153.
  5. Al Shareef SM, Basit S, Pfister C, Pradervand S, Lecendreux M, Mayer G, Dauvilliers Y, Salpietro V, Houlden H, BaHammam AS, Tafti M (2018) Kleine-Levin syndrome is associated with LMOD3 variants. J Sleep Res e12718

Portions of content adapted from Wikipedias article on Kleine–Levin syndrome licensed under GNU FDL.


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