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Information about Lamotrigine

Lamotrigine is a widely used antiseizure medication.


Liver safety of Lamotrigine

It is a rare but well known cause of idiosyncratic liver injury, that can be severe and even fatal.

Mechanism of action of Lamotrigine

Lamotrigine (la moe' tri jeen) is a phenyltriazine and belongs to an anticonvulsant class of its own.  Lamotrigine is believed to inhibit the release of excitatory neurotransmitters, particularly glutamate and aspartate but may also act directly on sodium channels on neuronal cells. 

FDA approval information for Lamotrigine

Lamotrigine was approved for use in the United States for epilepsy in 1994 and it is still in common use. 

Clinical use of Lamotrigine

Lamotrigine is indicated for prevention and management of partial and generalized seizures either alone or in combination with other anticonvulsant agents.  Lamotrigine is also approved for use as a mood stabilizer in bipolar disorders.  It is used off-label for several other conditions, including peripheral neuropathy, neuropathic pain, migraine headaches and trigeminal neuralgia. 

Dosage and administration for Lamotrigine

Lamotrigine is available tablets of 25, 100, 150 and 200 mg in generic formulations and under the brand name Lamictal.  Pediatric formulations as chewable tablets are available in doses of 2, 5 and 25 mg.  The recommended starting dose is 25 mg taken orally once daily, escalating to a maximum dose of 400 mg in two divided doses daily. 

Side effects of Lamotrigine

Common side effects include somnolence, fatigue, nervousness, dizziness, and rash.

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