Lesinurad
Lesinurad (pronounced leh-sin-yoo-rad) is a medication used in the treatment of gout, a type of arthritis characterized by severe pain, redness, and tenderness in joints. It is often used in combination with a xanthine oxidase inhibitor, such as allopurinol or febuxostat, to reduce the levels of uric acid in the body.
Etymology
The name "Lesinurad" is derived from the chemical name of the drug, which is 2-[[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl]acetic acid. The "Lesin" part of the name is a contraction of the chemical name, while the "urad" part is a reference to its use in treating conditions related to uric acid.
Pharmacology
Lesinurad works by inhibiting the function of a protein in the kidneys called urate transporter 1 (URAT1). This protein is responsible for reabsorbing uric acid from the urine back into the blood. By blocking this protein, Lesinurad helps the kidneys to excrete more uric acid, thereby reducing the levels of uric acid in the body.
Related Terms
- Gout: A type of arthritis characterized by severe pain, redness, and tenderness in joints.
- Uric Acid: A waste product in the blood that can form crystals in the joints, causing gout.
- Xanthine Oxidase Inhibitor: A type of medication used to reduce the production of uric acid in the body.
- Allopurinol: A xanthine oxidase inhibitor often used in combination with Lesinurad.
- Febuxostat: Another xanthine oxidase inhibitor that can be used with Lesinurad.
- Urate Transporter 1 (URAT1): A protein in the kidneys that Lesinurad inhibits to help reduce uric acid levels.
External links
- Medical encyclopedia article on Lesinurad
- Wikipedia's article - Lesinurad
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