Leuprorelin
Leuprorelin
Leuprorelin (pronounced: loo-pro-REL-in), also known as leuprolide, is a manufactured version of a hormone used to treat prostate cancer, breast cancer, endometriosis, uterine fibroids, and early puberty. It is given by injection into a muscle or under the skin.
Etymology
The term "Leuprorelin" is derived from its chemical structure, which is a synthetic nonapeptide analog of naturally occurring gonadotropin-releasing hormone (GnRH).
Usage
Leuprorelin is used in the treatment of hormone-responsive cancers such as prostate cancer and breast cancer, and in the treatment of endometriosis and uterine fibroids. It is also used in pediatric patients to treat central precocious puberty.
Mechanism of Action
Leuprorelin acts as an agonist at pituitary GnRH receptors. By interrupting the normal pulsatile stimulation of, and thus desensitizing, the GnRH receptors, it indirectly downregulates the secretion of gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This leads to a decrease in testosterone levels in men and a decrease in estradiol levels in women.
Side Effects
Common side effects of leuprorelin include hot flashes, mood changes, skin changes, and changes in sexual interest. Severe side effects may include allergic reactions, long-term effects on bone health, and pituitary apoplexy.
See Also
- Gonadotropin-releasing hormone
- Prostate cancer
- Breast cancer
- Endometriosis
- Uterine fibroids
- Central precocious puberty
External links
- Medical encyclopedia article on Leuprorelin
- Wikipedia's article - Leuprorelin
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