Levallorphan

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Levallorphan

Levallorphan (pronounced: leh-vuh-LOR-fan) is a morphinan derivative that acts as an antagonist for the mu-opioid receptor. It was developed in the mid-20th century and has been used primarily in scientific research.

Etymology

The term "Levallorphan" is derived from its chemical structure, which is similar to that of the opioid analgesic morphine. The prefix "Lev-" refers to its levorotatory isomeric form.

Pharmacology

Levallorphan acts as an antagonist at the mu-opioid receptor, meaning it blocks the effects of opioid drugs. It has also been found to have partial agonist activity at the kappa-opioid receptor, which can produce dissociative effects.

Clinical Use

While Levallorphan was initially developed for use as an analgesic, its clinical use has been limited due to its psychoactive effects. However, it has been used in scientific research to study the effects of opioids and the role of different opioid receptors.

Related Terms

  • Morphinan: The class of chemicals that Levallorphan belongs to.
  • Antagonist: A substance that interferes with or inhibits the physiological action of another.
  • Mu-opioid receptor: A class of opioid receptors with high affinity for enkephalins and beta-endorphins.
  • Kappa-opioid receptor: A type of opioid receptor that binds to the kappa-opioid peptide.
  • Dissociative: A class of hallucinogen which distort perceptions of sight and sound and produce feelings of detachment.

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