Linkage map
Linkage Map
A Linkage Map (pronunciation: /ˈlɪŋkɪdʒ mæp/) is a type of Genetic map that shows the relative positions of Genes or DNA sequences on a Chromosome. The concept of a linkage map was first introduced by Thomas Hunt Morgan and his student Alfred Sturtevant in the early 20th century.
Etymology
The term "Linkage Map" is derived from the concept of Genetic linkage, which refers to the tendency of DNA sequences that are close together on a chromosome to be inherited together. The word "map" is used in the sense of a diagrammatic representation of the relative positions of genes.
Description
A Linkage Map is created by studying the inheritance patterns of a set of genetic markers, which are DNA sequences with known physical locations on a chromosome. The distance between markers is measured in Centimorgans (cM), a unit of measure that describes the frequency of recombination between markers. The closer two markers are to each other, the less likely they are to be separated during Meiosis, and thus the higher their linkage.
Related Terms
- Genetic map: A map of the relative positions of genetic loci on a chromosome, determined on the basis of how often the loci are inherited together.
- Physical map: A map of the physical distances between loci, genetic markers, or other physical traits on a chromosome.
- Genome: The complete set of genes or genetic material present in a cell or organism.
- Genetic marker: A gene or DNA sequence with a known location on a chromosome that can be used to identify individuals or species.
- Centimorgan: A unit of measure of genetic linkage.
- Meiosis: A type of cell division that reduces the number of chromosomes in the parent cell by half and produces four gamete cells.
External links
- Medical encyclopedia article on Linkage map
- Wikipedia's article - Linkage map
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