LOD score
LOD score
LOD score (Logarithm of the odds score) is a statistical measure used in genetic linkage analysis. Pronounced as /el.oʊ.diː skɔːr/.
Etymology
The term "LOD score" was first used in the field of genetic linkage analysis. The "LOD" is an acronym for "logarithm of odds". The term "score" refers to the statistical measure used to determine the likelihood of genetic linkage.
Definition
The LOD score is a statistical measure that compares the likelihood of obtaining the test data if two loci are linked, to the likelihood of observing the same data purely by chance. A LOD score of three or greater is generally taken to indicate sufficient evidence for linkage.
Calculation
The LOD score is calculated using the formula:
LOD = log10 ( (probability of obtaining test data if two loci are linked) / (probability of obtaining test data if two loci are not linked) )
Related Terms
- Genetic linkage: The tendency of DNA sequences that are close together on a chromosome to be inherited together during the meiosis phase of sexual reproduction.
- Locus (genetics): A fixed position on a chromosome, like the position of a gene or a marker (genetic marker).
- Meiosis: A type of cell division that reduces the number of chromosomes in the parent cell by half and produces four gamete cells. This process is required to produce egg and sperm cells for sexual reproduction.
- Genetic marker: A gene or DNA sequence with a known location on a chromosome that can be used to identify individuals or species.
External links
- Medical encyclopedia article on LOD score
- Wikipedia's article - LOD score
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