Lovastatin

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Information about Lovastatin

Lovastatin is a commonly used cholesterol lowering agent (statin) that is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy and rarely with clinically apparent acute liver injury.

Mechanism of action of Lovastatin

Lovastatin (loe" va stat' in) is an orally available inhibitor of hepatic 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the major rate-limiting enzyme in cholesterol synthesis. Like other members of its class (the “statins”), lovastatin lowers total serum cholesterol and low density lipoprotein (LDL) concentrations, thereby reducing the risk of atherosclerosis and its complications – myocardial infarction and stroke.

Clinical use of Lovastatin

Lovastatin is indicated for treatment of hypercholesterolemia in persons at high risk for coronary, cerebrovascular and peripheral artery disease. Lovastatin is available in tablets of 10, 20, 40 and 60 mg in generic forms and under the brand name Mevacor. Extended release forms (Altoprev) and fixed combinations with niacin (Advicor) are also available. The recommended adult dose is 10 to 80 mg daily in single or two divided doses based upon tolerability and lipid levels.

FDA approval information for Lovastatin

Lovastatin was approved for use in the United States in 1987, the first of this class of drugs to be commercially available. Lovastatin is a widely prescribed drug with more than 7 million prescriptions filled yearly.

Side effects of Lovastatin

Common side effects include muscle cramps, joint aches, headache and weakness.

Lipid lowering medications

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