Loxapine

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Information about Loxapine

Loxapine is a conventional antipsychotic used in the therapy of schizophrenia.

Liver safety of Loxapine

Loxapine therapy is commonly associated with minor serum aminotransferase elevations and in very rare instances has been linked to clinically apparent acute liver injury.

Mechanism of action of Loxapine

Loxapine (lox' a peen) is a dibenzoxazepine tricyclic derivative which appears to act by blocking dopamine type 2 (D2) receptors. Loxapine has other central and peripheral effects including anticholinergic and α-adrenergic blockade.

FDA approval information for Loxapine

Loxapine is indicated for the therapy of psychotic disorders and was approved for this use in the United States in 1976. In recent years, loxapine has been replaced in large part by the atypical antipsychotics, which have fewer extrapyramidal side effects.

Dosage and administration for Loxapine

Loxapine is available as tablets of 5, 10, 25 and 50 mg and in generic forms and under the brand name Loxitane. Recommended doses of oral loxapine are 10 mg twice daily initially, increasing to a maximum of 100 mg in divided doses daily. An aerosol formulation of loxapine has recently been developed that is recommended for use in acute agitation in patients with bipolar disorder or schizophrenia.

Side effects of Loxapine

Common side effects include drowsiness, dizziness, headache, blurred vision, dry mouth, and tremor. Loxapine, unlike many antipsychotic agents, is not associated with significant weight gain.

Antipsychotic agents

First Generation

Second Generation (Atypicals)


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