Macimorelin acetate
Macimorelin acetate (pronunciation: ma-si-mo-re-lin a-ce-tate) is a growth hormone secretagogue receptor agonist. It is used as a diagnostic agent in the evaluation of adult growth hormone deficiency (AGHD).
Etymology
The term "Macimorelin" is derived from its chemical structure, which is a synthetic peptide analogue of ghrelin, a hormone that stimulates the release of growth hormone. "Acetate" refers to the salt form of the drug, which enhances its stability and absorption in the body.
Pharmacology
Macimorelin acetate works by stimulating the pituitary gland to release growth hormone. It binds to the growth hormone secretagogue receptor in the pituitary gland, which leads to the release of growth hormone into the bloodstream. This mechanism of action is similar to that of natural ghrelin, but macimorelin is more potent and has a longer duration of action.
Clinical Use
Macimorelin acetate is used as a diagnostic agent in the evaluation of adult growth hormone deficiency (AGHD). It is administered orally in a single dose, and the patient's blood is then tested at regular intervals to measure the levels of growth hormone. If the levels are below a certain threshold, this indicates a deficiency of growth hormone.
Side Effects
Common side effects of macimorelin acetate include diarrhea, headache, and changes in taste. Less common side effects can include dizziness, fatigue, and upper respiratory tract infection.
Related Terms
External links
- Medical encyclopedia article on Macimorelin acetate
- Wikipedia's article - Macimorelin acetate
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