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Information about Metaxalone

Metaxalone is a centrally acting skeletal muscle relaxant that has been in use for more than 40 years. 

Liver safety of Metaxalone

Metaxalone has not been associated with serum aminotransferase elevations during therapy or with clinically apparent hepatic injury.

Mechanism of action of Metaxalone

Metaxalone (me tax' a lone) acts centrally as a skeletal muscle relaxant, but its efficacy and precise mechanism of action are not well documented.  Metaxalone was approved for use in the United States in 1962 and it remains a widely used muscle relaxant. 

Clinical use of Metaxalone

Current indications include the treatment of pain from acute musculoskeletal conditions and muscle spasms. 

Dosage and administration for Metaxalone

The recommended dosage is 800 mg orally three to four times daily.  Metaxalone is available by prescription only in 400 and 800 mg tablets in generic forms as well as under the commercial name Skelaxin.  Sparse data are available regarding metaxalone safety. 

Side effects of Metaxalone

Side effects are not common, but can include drowsiness, dizziness, headache, nausea, and dry mouth.

Muscle relaxants

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