Mitochondrial replacement therapy
Mitochondrial Replacement Therapy
Mitochondrial Replacement Therapy (mi-toh-kon-dree-al ree-plaice-ment ther-uh-pee), also known as MRT, is a medical procedure that involves the replacement of mitochondria in human eggs or embryos to prevent the transmission of mitochondrial diseases.
Etymology
The term "Mitochondrial Replacement Therapy" is derived from the words "mitochondria", which are the energy-producing organelles within cells, and "replacement therapy", which refers to the process of replacing a missing or deficient substance in the body.
Procedure
Mitochondrial Replacement Therapy involves the removal of the nuclear DNA from a woman's egg or embryo that has defective mitochondria. This nuclear DNA is then inserted into a donor egg or embryo that has healthy mitochondria but has had its own nuclear DNA removed. The resulting egg or embryo contains nuclear DNA from the intended parents and mitochondrial DNA from the donor.
Related Terms
- Mitochondria: The organelles within cells that produce energy.
- Nuclear DNA: The DNA located in the nucleus of a cell, which contains most of the genetic information.
- Mitochondrial DNA: The DNA located in the mitochondria of a cell, which is passed down from mother to child.
- Mitochondrial Disease: A group of disorders caused by dysfunctional mitochondria.
- Gene Therapy: A technique that uses genes to treat or prevent disease.
See Also
External links
- Medical encyclopedia article on Mitochondrial replacement therapy
- Wikipedia's article - Mitochondrial replacement therapy
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