Mitoxantrone

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Mitoxantrone

Mitoxantrone (pronunciation: /maɪˈtɒksænˌtroʊn/) is a type of anthracenedione antineoplastic agent used in the treatment of certain types of cancer, including leukemia, breast cancer, and prostate cancer. It is also used to treat multiple sclerosis.

Etymology

The term "Mitoxantrone" is derived from the chemical name 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]]amino-9,10-anthracenedione dihydrochloride.

Usage

Mitoxantrone works by intercalating into the DNA and producing both single and double strand breaks, as well as interstrand crosslinks. This results in an inhibition of DNA replication and RNA synthesis.

Side Effects

Common side effects of Mitoxantrone include nausea, hair loss, and fatigue. More serious side effects may include heart disease, leukemia, and infections due to low blood cell counts.

Related Terms

  • Anthracycline: A class of drugs that are structurally related to Mitoxantrone and are also used as antineoplastic agents.
  • Doxorubicin: An anthracycline drug used in cancer chemotherapy that is structurally similar to Mitoxantrone.
  • Daunorubicin: Another anthracycline drug used in cancer chemotherapy that is structurally similar to Mitoxantrone.

See Also

External links

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