Monalazone

Monalazone', known in its disodium salt form as monalazone disodium (International Nonproprietary Name: INN), is a chemical compound employed as a vaginal disinfectant or antiseptic and as a spermicidal contraceptive. Marketed under brand names such as Naclobenz-Natrium, Spergisin, and Speton, monalazone is a derivative of sulfonylbenzoic acid, bearing a close structural resemblance to halazone, another antiseptic compound. First synthesized in 1937, monalazone's applications in medical and contraceptive products highlight its role in reproductive health and hygiene.

Pronunciation

Mo-na-la-zone

Chemical Properties and Synthesis

Monalazone is classified as a sulfonylbenzoic acid derivative, indicating its chemical lineage and functional characteristics related to its antiseptic and spermicidal properties. The synthesis of monalazone in 1937 marked a significant development in the search for effective antiseptic agents suitable for vaginal application. Its structural similarity to halazone suggests a related mechanism of action, primarily through the disruption of microbial cell processes.

Applications

Monalazone has been utilized primarily as a vaginal disinfectant and antiseptic agent, offering protection against microbial infections. Additionally, its spermicidal properties have been harnessed in contraceptive formulations to prevent pregnancy. A notable formulation combined 0.125 mg of estradiol benzoate, a form of estrogen, with 10 mg of monalazone, marketed under the brand name Malun 25. This combination highlights the dual functionality of monalazone in reproductive health, serving both contraceptive and therapeutic purposes.

Brand Names and Formulations

Under various brand names, monalazone has been incorporated into products designed for vaginal health. The combination of monalazone with estradiol benzoate in Malun 25 exemplifies its application in hormone-related therapeutic regimens, providing an example of how chemical compounds can be integrated into multifunctional pharmaceutical products.

Related Terms

• Vaginal Disinfectant
• Spermicidal Contraceptive
• Sulfonylbenzoic Acid Derivative
• Estradiol Benzoate

See Also

• Antiseptic
• Contraception
• Chemical Synthesis
• Reproductive Health

External links

• Medical encyclopedia article on Monalazone
• Wikipedia's article - Monalazone

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