Multiple endocrine neoplasia type 2B

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Multiple endocrine neoplasia type 2B (MEN 2B) is a rare genetic disorder characterized by the development of multiple neoplasms in various endocrine glands.

Pronunciation

Multiple endocrine neoplasia type 2B is pronounced as "mul-ti-pul en-do-crine ne-o-pla-sia type two B".

Etymology

The term "Multiple endocrine neoplasia type 2B" is derived from the following roots: "multiple" (many), "endocrine" (relating to glands that secrete hormones directly into the blood), "neoplasia" (the formation or presence of a new, abnormal growth of tissue), and "type 2B" (a specific subtype of the condition).

Related Terms

  • Neoplasm: An abnormal mass of tissue as a result of neoplasia. Neoplasms may be benign (not cancerous) or malignant (cancerous).
  • Endocrine Glands: Glands of the endocrine system that secrete their products, hormones, directly into the blood rather than through a duct.
  • Genetic Disorder: A disease caused in whole or in part by a change in the DNA sequence away from the normal sequence.

Symptoms

MEN 2B is associated with the development of medullary thyroid carcinoma, pheochromocytoma, and mucosal neuromas. Other symptoms may include a marfanoid habitus, eye abnormalities, and digestive problems.

Diagnosis

Diagnosis of MEN 2B typically involves genetic testing, as the condition is caused by mutations in the RET proto-oncogene. Other diagnostic methods may include blood tests, imaging studies, and biopsy of suspicious neoplasms.

Treatment

Treatment for MEN 2B is typically focused on managing symptoms and preventing complications. This may involve surgery to remove neoplasms, medication to manage hormonal imbalances, and regular monitoring to detect new neoplasms as early as possible.

See Also

External links

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