COVID-19 transmission graph

Coronavirus: WHO declares COVID 19 a pandemic. Prevention | FAQs | COVID-19 portal

URGENT:COVID prophylaxis | Vitamin D | Latest research | NIH | CDC | Worldometer

NB:Did you know one coronavirus patient can infect 59,000 others if nothing is done? Dietary cholesterol may not raise cardiovascular risk! Ketogenic diet

Nitrofurantoin

From WikiMD
Jump to navigation Jump to search
Other languages:
English

An antibiotic used to treat urinary tract infections.

Information about Nitrofurantoin

Nitrofurantoin is an oral antibiotic widely used either short term to treat acute urinary tract infections or long term as chronic prophylaxis against recurrent infections.

Liver safety of Nitrofurantoin

Nitrofurantoin is one of the most common causes of drug induced liver disease and can cause either an acute or a chronic hepatitis-like syndrome that can be severe and lead to liver failure or cirrhosis.

Mechanism of action of Nitrofurantoin

Structurally, nitrofurantoin (nye" troe fure an' toyn) is a nitrated 5-member furan ring with a side chain of hydantoin. Nitrofurantoin inhibits several bacterial enzyme systems and has broad antibacterial activity. Its precise mechanism of action is not known. Importantly, antibacterial resistance to nitrofurantoin is rare, which makes it an attractive choice for long term treatment. In addition, nitrofurantoin is well absorbed orally and is rapidly excreted in the urine so that drug levels in urine are high while serum levels are minimal, which makes it an appropriate agent to treat urinary tract but not systemic infections.

FDA approval information for Nitrofurantoin

Nitrofurantoin was first approved for use in the United States in 1953 and is still in wide use with more than 5 million prescriptions filled yearly. Current indications are treatment of acute and prophylaxis against chronic or recurrent urinary tract infections due to susceptible organisms.

Dosage and administration for Nitrofurantoin

For treatment of acute infections, the recommended regimen is 50 to 100 mg orally four times daily for one week. For prophylaxis against chronic or recurrent infections, the recommended dose is 50 to 100 mg daily long term.

Template:Generic Generic formulations are available (25, 50, and 100 mg); specific commercial names include Macrodantin, Macrobid and Furadantin, among others.

Side effects of Nitrofurantoin

Common side effects include nausea, diarrhea, dyspepsia, dizziness, drowsiness and rash. Nitrofurantoin has multiple rare, but potentially severe side effects that arise particularly with long term use and include interstitial pneumonitis, peripheral neuropathy, exfolative dermatitis, hemolytic anemia, lupus-like syndromes and hepatotoxicity.

Antibiotics

Antibacterial agents

antitoxins

leprosy agents

Other anti-infective agents


The article on Nitrofurantoin is a stub. YOU can help Wikimd by expanding it!

Medication resources

Learn more

Apple bitten.svg

WikiMD is a free medical encyclopedia and wellnesspedia moderated by medical professionals.

Help WikiMD: Find something you can improve? Join WikiMD as an an editor and help improve the page Nitrofurantoin or others.

W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's insurance Weight loss program can HELP*

Other languages:
English

Quick links: Medicine Portal | Encyclopedia‏‎‏‎ | Gray's Anatomy‏‎ | Topics‏‎ |‏‎ Diseases‏‎ | Drugs | Wellness | Obesity‏‎ | Metabolic syndrome | Weight loss*
Disclaimer: The entire contents of WIKIMD.ORG are for informational purposes only and do not render medical advice or professional services. If you have a medical emergency, you should CALL 911 immediately! Given the nature of the wiki, the information provided may not be accurate, misleading and or incorrect. Use the information on this wiki at your own risk! See full Disclaimer.
Link to this page: <a href="http://www.wikimd.org/wiki/Nitrofurantoin">Nitrofurantoin</a>

  • Individual results may vary for weight loss from our sponsors.