Doctor in scrubs


W8MD Diet | COVID-19 portal | Vitamin D | Vaccine | Keto

WikiMD is the world's largest medical encyclopedia with
28,794 pages, 4,106,893 edits & 35,575,713 views.

Free unbiased diet, health and wellness info!

Nizatidine

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search

Information about Nizatidine

Nizatidine is a histamine type 2 receptor antagonist (H2 blocker) which is widely used for treatment of acid-peptic disease and heartburn. 

Nizatidine
Nizatidine

Liver safety of Nizatidine

Nizatidine has been linked to rare instances of clinically apparent acute liver injury.

Mechanism of action of Nizatidine

Nizatidine (nye za' ti deen) was the fourth histamine type 2 receptor blocker (H2 blocker) introduced into clinical practice in the United States and is a commonly used agent for treatment of duodenal and gastric ulcer and gastroesophageal reflux disease.  Other H2 blockers in clinical use include cimetidine, ranitidine and famotidine.  The H2 blockers are specific antagonists of the histamine type 2 receptor, which is found on the basolateral (antiluminal) membrane of gastric parietal cells.  The binding of the agent to the H2 receptor results in inhibition of acid production and secretion, and improvement in symptoms and signs of acid-peptic disease.  The H2 blockers inhibit an early, “upstream” step in gastric acid production and are less potent that the proton pump inhibitors, which inhibit the final common step in acid secretion.  Nevertheless, the H2 blockers inhibit 24 hour gastric acid production by about 70% and are most effective in blocking basal and nocturnal acid production. 

FDA approval information for Nizatidine

Nizatidine was first approved for use in the United States in 1988 and is now available both by prescription and over-the-counter.  The listed indications for nizatidine are duodenal and gastric ulcer disease, gastroesophageal reflux and prevention of stress ulcers.  Nizatidine is available by prescription in capsules of 150 and 300 mg in several generic forms and in both oral and parenteral forms under the brand name Axid.  Over-the-counter preparations of nizatidine are usually tablets of 75 mg (Axid-AR). 

Side effects of Nizatidine

Side effects are uncommon, usually minor, and include diarrhea, constipation, fatigue, drowsiness, headache and muscle aches.

The antiulcer agents in clinical use

Proton Pump Inhibitors

Selective Histamine Type 2 Receptor Antagonists or H2 Blockers

Cost and Coupons - Nizatidine

Reviews for Nizatidine

Learn more about Nizatidine

Latest research (Pubmed)

PubMed
Wikipedia

External links


edit 

WikiMD needs you!

This WikiMD article Nizatidine is a stub.
If you are a healthcare professional familiar with the topic Nizatidine, or
A subject matter expert or authority on Nizatidine, you can help us.
About | Mission | Paid editors welcome!

Nizatidine is part of WikiMD's Physician reviewed^ articles available 4free, 4all, 4ever!
Medicine: Health - Encyclopedia‏‎‏‎ - Topics‏‎ -‏‎ Diseases‏‎ - Cancer - Rare diseases - Random Page Navigation: Drugs - Wellness - Obesity‏‎ - Diet - Ketogenic diet - W8MD weight loss diet - Editors: Recently Edited Pages - Alphabetical Order - Sponsors - USMLE The content on or accessible through WikiMD is for informational purposes only. WikiMD is not a substitute for professional medical advice. ^See full Disclaimers
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP*
Special: W8MD's tele-weight loss consultations only $99.99. Call 718-946-5500. Limited acceptance.