Non-Langerhans cell histiocytosis
Non-Langerhans cell histiocytosis (pronunciation: non-LAN-ger-hanz cell his-tee-oh-sigh-TOE-sis) is a rare type of histiocytosis, a group of diseases that involve an abnormal increase in the number of immune cells known as histiocytes. This condition is characterized by the accumulation of histiocytes that do not originate from the Langerhans cells, a type of dendritic cell that normally helps the body fight off infections.
Etymology
The term "Non-Langerhans cell histiocytosis" is derived from the name of the German physician Paul Langerhans, who first described the Langerhans cells, and the Greek words "histio" (tissue) and "cytosis" (condition of cells), indicating an abnormal condition of tissue cells.
Types
Non-Langerhans cell histiocytosis can be classified into several types, including:
- Juvenile xanthogranuloma
- Rosai-Dorfman disease
- Erdheim-Chester disease
- Adult xanthogranuloma
- Reticulohistiocytosis
Each type is characterized by different symptoms, causes, and treatment options.
Symptoms
The symptoms of Non-Langerhans cell histiocytosis can vary widely depending on the type and the organs affected. Common symptoms may include skin lesions, bone pain, and organ dysfunction.
Diagnosis
Diagnosis of Non-Langerhans cell histiocytosis typically involves a combination of physical examination, medical history, and laboratory tests. A biopsy of the affected tissue is often necessary to confirm the diagnosis.
Treatment
Treatment for Non-Langerhans cell histiocytosis depends on the type and severity of the disease. It may include surgery, radiation therapy, chemotherapy, or targeted therapies.
See also
External links
- Medical encyclopedia article on Non-Langerhans cell histiocytosis
- Wikipedia's article - Non-Langerhans cell histiocytosis
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