Nude mouse

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Nude mouse

A Nude mouse (/njuːd maʊs/), scientifically known as athymic mouse, is a type of laboratory mouse which has a genetic mutation that causes a deteriorated or absent thymus, resulting in an inhibited immune system due to a greatly reduced number of T cells. The mouse is called "nude" because it is also hairless. This type of mouse is often used in scientific research such as oncology studies and other immunology-related experiments.

Etymology

The term "Nude mouse" is derived from the acronym NUDE which stands for Nude, Uniform, Deficient, Expression. The term was coined due to the mouse's lack of hair and deficient immune system.

Related Terms

  • Thymus: An organ of the immune system, which is absent or deteriorated in the Nude mouse.
  • T cells: A type of white blood cell that is of key importance to the immune system and is at the core of adaptive immunity, the system that tailors the body's immune response to specific pathogens.
  • Oncology: The study of cancer. Nude mice are often used in oncology research due to their inhibited immune system.
  • Immunology: The branch of medicine and biology concerned with immunity. Nude mice are used in immunology-related experiments due to their greatly reduced number of T cells.
  • Genetic mutation: A permanent alteration in the DNA sequence that makes up a gene. The Nude mouse has a genetic mutation that causes a deteriorated or absent thymus.

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