Oleoylethanolamide

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Oleoylethanolamide

Oleoylethanolamide (pronunciation: o-leo-yl-eth-anol-amide), often abbreviated as OEA, is a naturally occurring lipid that plays a crucial role in the regulation of feeding and body weight. It is an endogenous peroxisome proliferator-activated receptor alpha (PPAR-Alpha) agonist.

Etymology

The term "Oleoylethanolamide" is derived from its chemical structure. "Oleoyle" refers to the oleoyl group, which is a fatty acid derived from oleic acid. "Ethanolamide" refers to the ethanolamine group, which is a primary amine and primary alcohol.

Function

Oleoylethanolamide is produced in the small intestine following feeding and acts locally to decrease food intake and increase lipid catabolism. It achieves this by binding to PPAR-Alpha, a nuclear receptor that regulates lipid metabolism.

Related Terms

  • PPAR-Alpha: A nuclear receptor that regulates lipid metabolism.
  • Lipid: A group of naturally occurring molecules that include fats, waxes, sterols, fat-soluble vitamins, monoglycerides, diglycerides, triglycerides, phospholipids, and others.
  • Oleic Acid: A monounsaturated fatty acid that is the most common fatty acid in human cells.
  • Ethanolamine: A primary amine and primary alcohol, which is used in the synthesis of a variety of chemical compounds.

See Also

External links

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