Orphenadrine

From WikiMD

Information about Orphenadrine

Orphenadrine is a centrally acting muscle relaxant that has been in clinical use for more than 50 years and has not been linked to liver injury or clinically apparent drug induced liver disease.

Mechanism of action of Orphenadrine

Orphenadrine (or fen' a dreen) is a centrally acting, nonopiate analgesic and muscle relaxant.  It is a methyl derivative of diphenhydramine (a commonly used antihistamine), but its mechanism of action in causing analgesia and skeletal muscle relaxation is not well defined.  Orphenadrine has anticholinergic activity and may act centrally on pain perception. 

FDA approval information for Orphenadrine

Orphenadrine is currently used for the treatment of acute, painful musculoskeletal conditions and can be given orally or parenterally.  Orphenadrine was approved for use as a muscle relaxant in the United States in 1957 and it is still in wide use. 

Brand name for Orphenadrine

Orphenadrine is available in multiple generic forms as standard and extended release tablets of 100 mg.  It is also available under commercial names such as Norgesic, Norflex, Deenar, Banflex, Disipal and X-Otag.  The recommended dosage is 100 mg twice daily.  Orphenadrine is also available in parenteral formulations under the names of Flexoject and Myolin.  The parenteral dose recommendation is 60 mg either intravenously or intramuscularly twice daily. 

Side effects of Orphenadrine

The most common side effects are those typical of anticholinergics including drowsiness, dry mouth, diaphoresis, flushing, confusion and visual disturbances.  Orphenadrine also has a potential for abuse and fatal overdoses have been reported.


Muscle relaxants


The article on Orphenadrine is a stub. YOU can help Wikimd by expanding it!

Medication resources

Learn more

Apple bitten.svg

About us: WikiMD is a free medical encyclopedia and wellnesspedia moderated by medical professionals.

Our mission: Provide up to date physician reviewed health, nutrition and wellness information.

Join us: Do not trust amateurs with your life! Join us in this effort!

W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's insurance Weight loss program can HELP*

Quick links: Medicine Portal | Encyclopedia‏‎‏‎ | Gray's Anatomy‏‎ | Topics‏‎ |‏‎ Diseases‏‎ | Drugs | Wellness | Obesity‏‎ | Metabolic syndrome | Weight loss*
Disclaimer: The entire contents of WIKIMD.ORG are for informational purposes only and do not render medical advice or professional services. If you have a medical emergency, you should CALL 911 immediately! Given the nature of the wiki, the information provided may not be accurate, misleading and or incorrect. Use the information on this wiki at your own risk! See full Disclaimer.
Link to this page: <a href="http://www.wikimd.org/wiki/Orphenadrine">Orphenadrine</a>

  • Individual results may vary for weight loss from our sponsors.