Osteopontin
Osteopontin
Osteopontin (pronounced: os·te·o·pon·tin) is a glycoprotein that plays a crucial role in the mineralization of bone and biomineralization processes. The term "Osteopontin" is derived from the Greek words "osteo" meaning bone and "pontin" meaning bridge, which reflects its function as a bridge between cells and the extracellular matrix.
Function
Osteopontin is secreted by osteoblasts, the cells responsible for bone formation, and is involved in the regulation of bone mineralization. It also plays a role in various biological processes, including cell adhesion, cell migration, and immune response.
Clinical Significance
Increased levels of Osteopontin have been associated with various pathological conditions, including osteoporosis, cancer, kidney disease, and cardiovascular disease. It is also considered a potential biomarker for certain types of cancer.
Related Terms
- Osteoblasts: Cells that synthesize bone.
- Bone Mineralization: The process by which bones gain minerals and become harder.
- Cell Adhesion: The binding of a cell to another cell, or to an extracellular matrix.
- Cell Migration: The movement of cells from one location to another.
- Immune Response: The body's defensive reaction to foreign substances.
- Osteoporosis: A condition characterized by weak and brittle bones.
- Cancer: A group of diseases characterized by uncontrolled cell growth.
- Kidney Disease: A condition that impairs the kidneys' ability to filter waste from the blood.
- Cardiovascular Disease: A class of diseases that involve the heart or blood vessels.
External links
- Medical encyclopedia article on Osteopontin
- Wikipedia's article - Osteopontin
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