PF-4800567
PF-4800567
PF-4800567 (pronunciation: P-F-four-eight-zero-zero-five-six-seven) is a pharmaceutical compound developed by Pfizer. It is a selective inhibitor of the Casein Kinase 1 epsilon (CK1ε) isoform, which is involved in various cellular processes including circadian rhythm regulation.
Etymology
The name "PF-4800567" is derived from the initials of the pharmaceutical company Pfizer (PF), followed by a unique numerical identifier (4800567) assigned to the compound during its development phase.
Mechanism of Action
PF-4800567 works by selectively inhibiting the CK1ε isoform, a protein kinase that phosphorylates serine and threonine residues in various proteins. This inhibition disrupts the normal function of CK1ε, which can affect a variety of cellular processes, including the regulation of the circadian rhythm.
Related Terms
- Pfizer: The pharmaceutical company that developed PF-4800567.
- Casein Kinase 1: A family of protein kinases, of which CK1ε is a member.
- Circadian rhythm: A natural, internal process that regulates the sleep-wake cycle and repeats roughly every 24 hours. It can be affected by the inhibition of CK1ε.
- Protein kinase: A type of enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation).
See Also
External links
- Medical encyclopedia article on PF-4800567
- Wikipedia's article - PF-4800567
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