PTGS
PTGS
PTGS (pronounced: P-T-G-S), also known as Prostaglandin-Endoperoxide Synthase is an enzyme that in humans is encoded by the PTGS gene.
Etymology
The term PTGS is an acronym derived from the full name of the enzyme, Prostaglandin-Endoperoxide Synthase. The term "prostaglandin" comes from the prostate gland where the compound was first discovered. "Endoperoxide" refers to the peroxide group in the enzyme's structure. "Synthase" is a class of enzymes that catalyze the formation of a particular substance.
Function
PTGS is an enzyme that plays a key role in the production of prostaglandins, which are lipid compounds that have diverse functions in the body, including roles in inflammation, fever, and pain. This enzyme is involved in the conversion of arachidonic acid to prostaglandin H2, a precursor of various prostaglandins and thromboxanes, which are potent mediators of inflammation.
Related Terms
- Prostaglandins: A group of physiologically active lipid compounds having diverse hormone-like effects in animals.
- Arachidonic Acid: A polyunsaturated omega-6 fatty acid involved in the synthesis of prostaglandins.
- Thromboxanes: A member of the family of lipids known as eicosanoids, produced by the enzyme PTGS.
See Also
- Cyclooxygenase: Another name for the PTGS enzyme, referring to its role in the formation of oxides of prostaglandin.
- Nonsteroidal anti-inflammatory drug: A class of drugs that inhibit the PTGS enzyme and are often used to relieve pain and inflammation.
External links
- Medical encyclopedia article on PTGS
- Wikipedia's article - PTGS
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