Logo


W8MD Diet | COVID-19 portal | Vitamin D | Vaccine | Keto

WikiMD is the world's largest medical encyclopedia with
14,007 pages, 4,159,090 edits & 43,392,504 views.

Free unbiased diet, health and wellness info!

Paclitaxel

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search

Information about Paclitaxel

Paclitaxel is an antineoplastic agent which acts by inhibitor of cellular mitosis and which currently plays a central role in the therapy of ovarian, breast, and lung cancer. 

Liver safety of Paclitaxel

Therapy with paclitaxel has been associated with a low rate of serum enzyme elevations, but has not been clearly linked to cases of clinically apparent acute liver injury.

Mechanism of action of Paclitaxel

Paclitaxel (pak" li tax' el) is a complex diterpenoid molecule that contains a central 8-member taxane ring.  Paclitaxel was initially isolated from the bark of the Western Yew tree (Taxus breviflora) and found to have antitumor activity in high throughput assays.  It is a potent antineoplastic agent and its mechanism of action appears to be mediated by its binding to microtubulin, which is important in the mitototic phase of cell division.  The binding of paclitaxel prevents the disassembly of the cytoskeletal microtubules, preventing cell division and leading to cell death. 

FDA approval information for Paclitaxel

Paclitaxel was approved for use in the United States in 1992 and it remains an important agent in the therapy of several cancers.  Paclitaxel is considered a first line treatment for advanced ovarian carcinoma and is also used in breast cancer and advanced non-small cell lung cancer and AIDS-related Kaposi's sarcoma.

Dosage and administration for Paclitaxel

Paclitaxel is available in solution for injection (6 mg/mL) generically and under the brand names Taxol and Onxol.  Paclitaxel is also available as protein bound particles in a lyphophilized powder for injection under the brand name Abraxane.  Paclitaxel is administered intravenously, typically as 3 to 24 hour infusions every three weeks in cycles in combination with other antineoplastic agents.  The dose varies by indication and body weight and is reduced in persons with preexisting liver disease. 

Side effects of Paclitaxel

Side effects are common and include diarrhea, nausea, vomiting, mucositis, fatigue, mylagias, skin rash, alopecia, phlebitis, bone marrow suppression, fluid retention, cardiomyopathy, peripheral neuropathy and hypersensitivity reactions. 

Alphabetic list of antineoplastic agents - 0-9 - A1 - A2 - A3 - A4 - A5 -A6 - B - C - D - E - F - G - H - I - JK - L - M - NO - PQ - R - S - T - UVW - XYZ

 

Cost and Coupons - Paclitaxel

Reviews for Paclitaxel

Learn more about Paclitaxel

Latest research - Paclitaxel

PubMed
Clinical trials

External links

Wikipedia
Medicine icon
Medicine icon

This WikiMD article Paclitaxel is a stub. If you are familiar with the topic Paclitaxel, you can help us. Paid editors welcome!

 

Paclitaxel is part of WikiMD's free ^articles!

^Paclitaxel (article) is provided for informational purposes only. No expressed or implied warranties as to the validity of content.
WikiMD is not a substitute for professional advice. By accessing and using WikiMD you agree to the terms of use.
Templates etc. when imported from Wikipedia, are licensed under CC BY-SA 3.0. See full disclaimers.
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP. Tele medicine available