Paget's disease of bone
Paget's disease of bone
Paget's disease of bone (pronounced: PAH-jets) is a chronic disorder that can result in enlarged and misshapen bones. The etymology of the term is derived from the name of Sir James Paget, a British surgeon and pathologist who first identified the condition in 1877.
Definition
Paget's disease of bone interferes with your body's normal recycling process, in which new bone tissue gradually replaces old bone tissue. Over time, the disease can cause affected bones to become fragile and misshapen.
Symptoms
The disease can be symptomless and is often discovered accidentally when an X-ray or blood test is done for another reason. When symptoms do occur, they can include bone pain, joint pain (particularly in the hip), a waddling walk, and hearing loss if the skull is affected.
Causes
The exact cause of Paget's disease of bone is unknown, but it is suspected to be related to a slow viral infection of the bone or a genetic predisposition. Some researchers believe that genetic factors may make certain individuals more susceptible to the disease.
Treatment
Treatment for Paget's disease of bone aims to manage symptoms and prevent complications. This may include pain relievers, bisphosphonates, and surgery in severe cases.
Related Terms
- Osteoporosis: A condition in which bones become weak and brittle.
- Bone remodeling: The process by which old bone is replaced by new bone tissue.
- Bisphosphonates: A class of drugs that inhibit the resorption of bone by osteoclasts.
External links
- Medical encyclopedia article on Paget's disease of bone
- Wikipedia's article - Paget's disease of bone
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