Paget disease of bone
Paget disease of bone (pronounced: pa-jet) is a chronic disorder that can result in enlarged and misshapen bones. The etymology of the term is derived from the name of Sir James Paget, a British surgeon who first described the condition in 1877.
Definition
Paget disease of bone interferes with your body's normal recycling process, in which new bone tissue gradually replaces old bone tissue. Over time, the disease can cause affected bones to become fragile and misshapen.
Symptoms
The disease can affect any bone in the body, but most people have symptoms in the pelvis, skull, spine, and leg bones. Symptoms can include bone pain, joint pain, and bone deformity.
Causes
The exact cause of Paget disease of bone is unknown, but it is believed to involve a combination of genetic and environmental factors. Some researchers believe a viral infection early in life may make a person more likely to develop the disease later.
Diagnosis
Diagnosis of Paget disease of bone involves a physical examination, discussion of your symptoms and medical history, and possibly imaging tests such as X-rays or bone scans. Blood tests may also be done to measure levels of an enzyme called alkaline phosphatase, which is often elevated in people with Paget disease of bone.
Treatment
Treatment for Paget disease of bone aims to manage symptoms and prevent complications. This may involve medications to slow the rate of bone turnover, such as bisphosphonates, and in severe cases, surgery may be needed.
Related Terms
External links
- Medical encyclopedia article on Paget disease of bone
- Wikipedia's article - Paget disease of bone
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