W8MD Diet | COVID-19 portal | Vitamin D | Vaccine | Keto

WikiMD is the world's largest medical encyclopedia with
13,590 pages, 4,139,115 edits & 37,811,477 views.

Free unbiased diet, health and wellness info!


From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search

Information about Palbociclib

Palbociclib is a unique cyclin-dependent kinase inhibitor that is used in combination with aromatase inhibitors in the treatment of postmenopausal women with metastatic breast cancer.


Liver safety of Palbociclib

Palbociclib is associated with transient and usually mild elevations in serum aminotransferase during therapy, but has yet to be linked to cases of clinically apparent acute liver injury.   

Mechanism of action of Palbociclib

Palbociclib (pal" boe sye' klib) is an orally available, specific inhibitor of cyclin-dependent kinases that is used in combination with aromatase inhibitors in the therapy of postmenopausal women with metastatic breast cancer that is positive for the estrogen receptor (ER+), but negative for human epidermal growth factor receptor 2 (HER2-).  The cyclin kinases 4 and 6 regulate the cellular transition from the G1 to the S phase of the cell cycle.  Inhibition of this transition blocks the progression of the cell cycle and results in growth arrest in rapidly dividing cells.  The addition of palbociclib to letrozole or fulvestrant (aromatase inhibitors) therapy of metastatic breast cancer (ER+, HER2-) in postmenopausal women was associated with a prolongation of disease free survival. 

FDA approval information for Palbociclib

Palbociclib received accelerated approval for use in the United States in 2015, and it is still under close evaluation for its long term safety and efficacy. 

Dosage and administration for Palbociclib

Palbociclib is available in capsules of 75, 100 and 125 mg and the typical maintenance dose is 125 mg once daily in 21 day cycles every 28 days indefinitely or until there is disease progression. 

Side effects of Palbociclib

Common side effects include fatigue, nausea, diarrhea, anorexia, neutropenia, fever, anemia, thrombocytopenia, epistasis, peripheral neuropathy and pulmonary embolism. Severe adverse events include neutropenia fever and sepsisAlphabetic list of antineoplastic agents - 0-9 - A1 - A2 - A3 - A4 - A5 -A6 - B - C - D - E - F - G - H - I - JK - L - M - NO - PQ - R - S - T - UVW - XYZ


Cost and Coupons - Palbociclib

Reviews for Palbociclib

Learn more about Palbociclib

Latest research - Palbociclib

Clinical trials

External links

Medicine icon
Medicine icon

This WikiMD article Palbociclib is a stub. If you are familiar with the topic Palbociclib, you can help us. Paid editors welcome!


Palbociclib is part of WikiMD's free ^articles!

^Palbociclib (article) is provided for informational purposes only. No expressed or implied warranties as to the validity of content.
WikiMD is not a substitute for professional advice. By accessing and using WikiMD you agree to the terms of use.
Templates etc. when imported from Wikipedia, are licensed under CC BY-SA 3.0. See full disclaimers.
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP. Tele medicine available