Pamrevlumab
Pamrevlumab
Pamrevlumab (pronunciation: pam-rev-loo-mab) is a monoclonal antibody designed to inhibit the activity of connective tissue growth factor (CTGF), a common factor in fibrotic and proliferative disorders.
Etymology
The name "Pamrevlumab" is derived from the standard nomenclature for therapeutic monoclonal antibodies, where "-lumab" signifies a human antibody, and "Pamrev" is a unique prefix.
Mechanism of Action
Pamrevlumab works by binding to and inhibiting the activity of CTGF, a protein that is overexpressed in fibrotic diseases. By blocking the action of CTGF, Pamrevlumab can reduce the progression of fibrosis and potentially reverse the damage caused by these diseases.
Clinical Trials
Pamrevlumab is currently in clinical trials for the treatment of several conditions, including idiopathic pulmonary fibrosis, pancreatic cancer, and Duchenne muscular dystrophy.
Related Terms
- Monoclonal antibody: A type of protein made in the lab that can bind to substances in the body, including cancer cells.
- Connective tissue growth factor (CTGF): A protein that is involved in the proliferation and differentiation of cells and plays a key role in the development of fibrosis.
- Fibrosis: The thickening and scarring of connective tissue, usually as a result of injury.
- Clinical trials: Research studies that test how well new medical approaches work in people.
- Idiopathic pulmonary fibrosis: A type of chronic lung disease characterized by a progressive and irreversible decline in lung function.
- Pancreatic cancer: A disease in which malignant (cancer) cells form in the tissues of the pancreas.
- Duchenne muscular dystrophy: A genetic disorder characterized by progressive muscle degeneration and weakness.
External links
- Medical encyclopedia article on Pamrevlumab
- Wikipedia's article - Pamrevlumab
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