Paramesonephric duct
Paramesonephric Duct
Paramesonephric duct (pronunciation: /ˌpærəˌmiːzoʊˈnɛfrɪk ˈdʌkt/), also known as the Müllerian duct, is a structure present during the embryonic development of mammals. The term "paramesonephric" is derived from the Greek words "para" (beside), "mesos" (middle), and "nephros" (kidney), indicating its location relative to the mesonephric duct in the embryo.
Development
The paramesonephric ducts are formed in the female embryo, parallel to the mesonephric duct. They develop into the female reproductive tract, including the fallopian tubes, uterus, cervix, and the upper part of the vagina. In males, the paramesonephric ducts regress due to the influence of anti-Müllerian hormone (AMH) secreted by the Sertoli cells of the testes.
Clinical Significance
Abnormalities in the development of the paramesonephric duct can lead to various congenital disorders, such as Mayer-Rokitansky-Küster-Hauser syndrome (MRKH), which is characterized by the underdevelopment or absence of the uterus and the upper part of the vagina.
Related Terms
- Mesonephric duct: The embryonic duct of the male reproductive system, which develops into the vas deferens.
- Anti-Müllerian hormone (AMH): A hormone responsible for the regression of the paramesonephric ducts in males.
- Mayer-Rokitansky-Küster-Hauser syndrome (MRKH): A congenital disorder resulting from abnormal development of the paramesonephric duct.
External links
- Medical encyclopedia article on Paramesonephric duct
- Wikipedia's article - Paramesonephric duct
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