Paterson-Kelly syndrome

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Paterson-Kelly Syndrome

Paterson-Kelly syndrome (pronounced: pætərsən kɛli sɪndroʊm), also known as Plummer-Vinson syndrome or Sideropenic dysphagia, is a rare medical condition characterized by difficulty in swallowing, iron-deficiency anemia, and esophageal webs.

Etymology

The syndrome is named after two British physicians, Donald Ross Paterson and Adam Brown-Kelly, who independently described the condition in the early 20th century. The term "sideropenic" is derived from the Greek words "sideros" (iron) and "penia" (lack), referring to the iron-deficiency anemia that is a key feature of the syndrome.

Symptoms

The primary symptoms of Paterson-Kelly syndrome include dysphagia (difficulty swallowing), iron-deficiency anemia, and the presence of esophageal webs. Other symptoms may include glossitis (inflammation of the tongue), cheilosis (inflammation of the lips), and koilonychia (spoon-shaped nails).

Diagnosis

Diagnosis of Paterson-Kelly syndrome typically involves a combination of endoscopy, barium swallow study, and blood tests to confirm iron-deficiency anemia. The presence of esophageal webs can be confirmed through endoscopy or barium swallow.

Treatment

Treatment for Paterson-Kelly syndrome primarily involves addressing the iron-deficiency anemia through iron supplementation and dietary changes. In some cases, endoscopic dilation may be required to manage esophageal webs.

Prognosis

With appropriate treatment, the prognosis for individuals with Paterson-Kelly syndrome is generally good. However, there is an increased risk of developing esophageal cancer in later life.

See also

External links

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