Alpha Interferon

From WikiMD

(Redirected from Peginterferon)

Information about Alpha Interferon

Alpha interferon is a cytokine produced by the innate immune system in response to environmental exposures including viral infections. Alpha interferon in various formulations has been developed as therapy of several forms of cancer and viral infections, but its major use has been as therapy of chronic hepatitis C. Alpha interferon therapy can be associated with transient, mild-to-moderate serum aminotransferase elevations and it has been linked to induction of autoimmune conditions, including autoimmune hepatitis in susceptible persons.

Mechanism of action of Alpha Interferon

Alpha interferon (in"' ter feer' on) is a naturally occurring cytokine which is produced by cells of the innate immune system in reaction to viral infection or other environmental stresses. Alpha and beta interferon are considered type I interferons which share antiviral, immunomodulatory as well as antiproliferative effects. The pathways of induction and actions of alpha interferon are quite complex and the antiviral effects are due to induction of multiple intracellular genes. Overall, type I interferons produce an antiviral state inside of cells that decreases viral replication and protects against infection. There are at least 20 copies of the alpha interferon gene in the human genome and multiple formulations of standard recombinant interferon have been produced (alfa-2a, alfa-2b and alfa-con1 or “consensus” interferon). Furthermore, the interferon molecule can be pegylated which causes a prolongation of its half-life, allowing for once weekly as opposed to daily or every other day administration. Because interferon is a protein, it must be given parenterally (usually subcutaneously). Recombinant human interferons were approved for use in cancer in the 1980s, for hepatitis B in 1991 and for hepatitis C in 1992. Peginterferon became available in 2000 and has largely replaced the standard preparations.

Dosage and administration for Alpha Interferon

The typical dose of peginterferon alfa-2a is 180 µg once weekly for 24 or 48 weeks, and for peginterferon alfa-2b 1.5 µg/kg once weekly for 24 to 48 weeks.

Clinical use of Alpha Interferon

In chronic hepatitis C, peginterferon is usually given with ribavirin and, more recently, as triple therapy with a protease inhibitor, such as boceprevir, telaprevir, simiprevir or sofosbuvir. Ultimately, oral antiviral regimens are likely to replace peginterferon therapy in chronic hepatitis C. Standard interferon alfa is also approved for use in hairy cell leukemia, malignant melanoma, follicular lymphoma and AIDS-related Kaposi's sarcoma. Local injections of interferon are used to treat condylomata acuminata.

Side effects of Alpha Interferon

Interferon has many side effects which often limit the dose and duration of therapy. The most common side effects include fatigue, muscle aches, headaches, depression, anxiety, bone marrow suppression and rash.

Antiviral agents

Drugs for HIV Infection, in the Subclass Antiretroviral Agents

Drugs for Hepatitis B

Drugs for Hepatitis C

HCV NS5A Inhibitors

HCV NS5B (Polymerase) Inhibitors

HCV Protease Inhibitors

Combination Therapies

Drugs for Herpes Virus Infections (HSV, CMV, others)

Drugs for Influenza


The article on Alpha Interferon is a stub. YOU can help Wikimd by expanding it!

Medication resources

Learn more


edit 

About WikiMD

About us: WikiMD is a free medical encyclopedia and wellnesspedia moderated by medical professionals.

Our mission: Provide up to date physician reviewed health, nutrition and wellness information for free in over 100 languages.

Join us: This article is a stub. Help improve Alpha Interferon or others. Do not trust amateurs with your life! Join us in this effort!. Paid editors welcome.

Pubmed.png Uptodate.png Wikipedia Reddit YouTube videos
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's insurance Weight loss program can HELP*

Quick links: Medicine Portal | Encyclopedia‏‎‏‎ | Gray's Anatomy‏‎ | Topics‏‎ |‏‎ Diseases‏‎ | Drugs | Wellness | Obesity‏‎ | Metabolic syndrome | Weight loss*
Disclaimer: The entire contents of WIKIMD.ORG are for informational purposes only and do not render medical advice or professional services. If you have a medical emergency, you should CALL 911 immediately! Given the nature of the wiki, the information provided may not be accurate, misleading and or incorrect. Use the information on this wiki at your own risk! See full Disclaimer.
Link to this page: <a href="http://www.wikimd.org/wiki/Alpha_Interferon">Alpha Interferon</a>

  • Individual results may vary for weight loss from our sponsors.