Pegvaliase
Pegvaliase
Pegvaliase (pronunciation: peg-VAL-i-ase) is a medication used in the treatment of phenylketonuria, a rare genetic disorder. It is marketed under the brand name Palynziq by BioMarin Pharmaceutical.
Etymology
The name "Pegvaliase" is derived from the medication's composition. "Peg" refers to polyethylene glycol, a component used to increase the medication's half-life in the body. "Valiase" is a reference to the enzyme phenylalanine ammonia lyase (PAL), which the medication is designed to replace in patients with phenylketonuria.
Usage
Pegvaliase is used to lower blood phenylalanine levels in adults with phenylketonuria who have uncontrolled blood phenylalanine levels on current treatment. It works by helping the body break down phenylalanine.
Related Terms
- Phenylketonuria: A rare genetic disorder in which the body can't process the amino acid phenylalanine.
- Phenylalanine: An essential amino acid that is not produced by the body and must be obtained from the diet.
- Phenylalanine ammonia lyase (PAL): An enzyme that breaks down phenylalanine in the body.
- Polyethylene glycol (PEG): A component used in many medications to increase their half-life in the body.
See Also
- BioMarin Pharmaceutical
- Phenylketonuria
- Phenylalanine
- Phenylalanine ammonia lyase
- Polyethylene glycol
External links
- Medical encyclopedia article on Pegvaliase
- Wikipedia's article - Pegvaliase
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