Pharmacological chaperone

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Pharmacological Chaperone

Pharmacological chaperones (pronunciation: /ˌfɑːrməkəˈlɒdʒɪkəl ˈʃæpəroʊn/), also known as pharmacoperones, are a type of small molecule that can enter cells and assist in the folding of proteins.

Etymology

The term "pharmacological chaperone" is derived from the Greek words "pharmakon" (meaning "drug") and "chaperone" (meaning "one who attends"). The term "chaperone" in this context is used to denote the role of these molecules in assisting the proper folding of proteins, similar to how a chaperone guides and assists in certain social situations.

Function

Pharmacological chaperones function by binding to and stabilizing proteins in their correct conformation, thereby increasing the efficiency of protein folding and reducing the likelihood of misfolding. This can be particularly beneficial in the treatment of diseases caused by protein misfolding, such as cystic fibrosis, Alzheimer's disease, and Parkinson's disease.

Related Terms

  • Protein folding: The process by which a protein structure assumes its functional shape or conformation.
  • Protein misfolding: The process by which proteins do not fold into their functional form.
  • Small molecule: A low molecular weight organic compound that may regulate a biological process.

See Also

External links

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