Phenelzine

From WikiMD
Jump to navigation Jump to search

Information about Phenelzine

Phenelzine is a monamine oxidase inhibitor (MAO inhibitor) used in therapy of severe depression.

Liver safety of Phenelzine

Phenelzine therapy is associated with rare instances of clinically apparent acute liver injury.

Mechanism of action of Phenelzine

Phenelzine (fen' el zeen) is a hydrazine derivative and antidepressant that acts through inhibition of monamine oxidase, an enzyme that inactivates several neurotransmitter amines such as norepinephrine and serotonin. By inhibition of catabolism of serotonin and norepinephrine, phenelzine increases brain levels of these neurotransmitters which probably underlie its antidepressant effects.

FDA approval information for Phenelzine

Phenelzine was approved for use as therapy of depression in the United States in 1961, but it is now rarely used because of the availability of more potent and better tolerated antidepressants such as the tricyclic antidepressants and the selective serotonin reuptake inhibitors.

Dosage and administration for Phenelzine

Phenelzine is available in generic forms and under the brand name of Nardil as tablets of 15 mg. The usual adult dose of phenelzine is 15 to 30 mg three times daily.

Side effects of Phenelzine

Common side effects include drowsiness, dizziness, headache, insomnia, tremor, dry mouth, nausea, increased appetite, weight gain and sexual dysfunction. Phenelzine interacts with many medications as well as many foods and beverages, and patients require careful monitoring and education.

The following antidepressant subclasses and drug records are discussed individually:

MAO Inhibitors Isocarboxazid, Phenelzine, Tranylcypromine

SNRIs Duloxetine, Levomilnacipran, Venlafaxine

SSRIs Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Vilazodone, Vortioxetine

Tricyclics Amitriptyline, Amoxapine, Clomipramine, Desipramine, Doxepin, Imipramine, Nortriptyline, Protriptyline, Trimipramine

Miscellaneous Bupropion, Flibanserin, Mirtazapine, Nefazodone, Trazodone


Cost and Coupons - Phenelzine

Reviews for Phenelzine


Wellness that matters!

Articles on Phenelzine

This article is a stub. YOU can help Wikimd by expanding it!

Learn more about Phenelzine

Drug classes

WikiMD resources 360 on Phenelzine - scientific articles to social media

Articles

Policies / Guidelines Social Media
Flickr

Media

Patient Resources / Community
Reddit
Facebook posts
Tweets

Evidence Based Medicine

Healthcare Provider Resources
YouTube videos
Tumblr

Clinical Trials

News
Yelp.png
Quora.png
Pins
Instagram
Bing.png
External:W8MD Weight Loss, Sleep & MedSpa Wellness Topics A-Z Other resources
W8md-logo.jpg

A | B | C | D | E | F | G

H | I | J | K | L | M | N

O | P | Q | R | S | T | U

V | W | X | Y | Z

Ad. Tired of being overweight? W8MD's insurance weight loss* program can HELP | Advertise on WikiMD

Disclaimer: The entire contents of WIKIMD.ORG are for informational purposes only and do not render medical advice or professional services. If you have a medical emergency, you should CALL 911 immediately! Given the nature of the wiki, the information provided may not be accurate and or incorrect. Use the information on this wiki at your own risk! See full Disclaimer. * Individual results may vary.