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Pitavastatin

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Information about Pitavastatin

Pitavastatin is a relatively newly developed cholesterol lowering agent (statin) that is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, but has had limited use and has yet to be linked with clinically apparent acute liver injury.

Mechanism of action of Pitavastatin

Pitavastatin (pi ta" va stat' in) is a potent, orally available inhibitor of hepatic 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase the major rate limiting enzyme in cholesterol synthesis. Like other members of its class (the “statins”), pitavastatin lowers total serum cholesterol and low density lipoprotein (LDL) concentrations, thereby reducing the risk of atherosclerosis and its complications – myocardial infarction and stroke.

FDA approval information for Pitavastatin

Pitavastatin was approved for use in the United States in 2009 but experience with its use is limited. Pitavastatin is indicated for treatment of hypercholesterolemia in persons at high risk for coronary, cerebrovascular and peripheral artery disease.

Dosage and administration for Pitavastatin

  • Pitavastatin is available in tablets of 1, 2 and 4 mg under the trade name Livalo. Pitavastatin is one of the more potent statins and is typically used in a comparably lower dose.
  • The recommended dose is 2 to 4 mg once daily based upon tolerability and lipid levels. Common side effects include muscle cramps, joint aches, headache and weakness.

Lipid lowering medications

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