Pleomorphic T-cell lymphoma

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Pleomorphic T-cell Lymphoma

Pleomorphic T-cell lymphoma (pronunciation: pleo-morphic T-cell lymph-oma) is a type of non-Hodgkin lymphoma that affects the T cells in the lymphatic system. The term "pleomorphic" refers to the ability of the cancer cells to assume various shapes.

Etymology

The term "pleomorphic" is derived from the Greek words "pleio", meaning more, and "morphē", meaning shape or form. This refers to the variable appearance of the cancer cells under a microscope. "T-cell" refers to a type of white blood cell that plays a central role in cell-mediated immunity. "Lymphoma" is derived from the Latin word "lympha", meaning water, and the Greek suffix "-oma", meaning mass or tumor.

Definition

Pleomorphic T-cell lymphoma is a subtype of peripheral T-cell lymphoma, characterized by the presence of large, abnormal T cells that can take on various shapes. These cancerous cells proliferate in the lymphatic system, leading to symptoms such as swollen lymph nodes, fatigue, and unexplained weight loss.

Symptoms

Common symptoms of pleomorphic T-cell lymphoma include:

  • Swollen, painless lymph nodes in the neck, armpits, or groin
  • Fatigue
  • Fever
  • Night sweats
  • Unexplained weight loss

Diagnosis

Diagnosis of pleomorphic T-cell lymphoma typically involves a biopsy of the affected lymph node. The tissue sample is then examined under a microscope to identify the presence of abnormal T cells. Additional tests, such as blood tests, imaging studies, and bone marrow biopsy, may be performed to determine the extent of the disease.

Treatment

Treatment for pleomorphic T-cell lymphoma typically involves chemotherapy, with or without radiation therapy. In some cases, a stem cell transplant may be considered.

Prognosis

The prognosis for pleomorphic T-cell lymphoma varies depending on the stage of the disease at diagnosis, the patient's overall health, and the response to treatment.

See also

External links

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