Pralidoxime chloride

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Pralidoxime chloride

Pralidoxime chloride (pronounced prah-li-DOX-eem KLOR-ide), also known as 2-PAM chloride, is a medication primarily used as an antidote in the treatment of organophosphate poisoning.

Etymology

The term "Pralidoxime" is derived from PRo-Amine LIgand DOXime, indicating its function as a pro-amine ligand doxime. The "chloride" refers to the chloride salt form of the drug.

Usage

Pralidoxime chloride works by reactivating acetylcholinesterase, an enzyme that is inhibited by organophosphates, thereby allowing normal function of the nervous system to resume. It is often used in conjunction with atropine, another antidote for organophosphate poisoning.

Related Terms

  • Organophosphate: A class of chemicals that includes many insecticides and nerve gases. Organophosphates inhibit acetylcholinesterase, leading to an accumulation of acetylcholine and resulting in overstimulation of the nervous system.
  • Acetylcholinesterase: An enzyme that breaks down acetylcholine, a neurotransmitter, in the synaptic cleft (the space between neurons) to allow the neuron to return to its resting state after activation.
  • Atropine: A medication used to treat certain types of nerve agent and pesticide poisonings, some types of slow heart rate, and to decrease saliva production during surgery.

See Also

External links

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