- 1 Information about Pregabalin
- 2 Liver safety of Pregabalin
- 3 Mechanism of action of Pregabalin
- 4 FDA approval information for Pregabalin
- 5 Dosage and administration for Pregabalin
- 6 Side effects of Pregabalin
- 7 Cost and Coupons - Pregabalin
- 8 Reviews for Pregabalin
- 9 Articles on Pregabalin
- 10 Learn more about Pregabalin
Information about Pregabalin
Pregabalin is an inhibitor of neuronal activity used for therapy of neuropathy and as an anticonvulsant.
Liver safety of Pregabalin
Therapy with pregabalin is not associated with serum aminotransferase elevations, and clinically apparent liver injury from pregabalin has been reported but appears to be quite rare.
Mechanism of action of Pregabalin
Pregabalin (pre gab' a lin) is a structural analogue of gamma-aminobutyric acid (GABA) but is novel in its activity, having no effects on GABA-A or GABA-B receptors. Instead, the neuronal acitivity of pregabalin appears to be mediated by its binding to the alpha-2-delta subunit of the presynaptic voltage-gated calcium channel whcih leads to a decrease in release of neuroexcitatory neurotransmitters by hyperexcited neurons. Pregabalin has been shown to be effective in reducing neuropathic pain from diabetic and postherpetic neuropathy and is an effective anticonvulsant.
FDA approval information for Pregabalin
Pregabalin was approved for use in the United States in 2004. Current indications include diabetic and post-herpetic neuropathy and as adjunctive therapy of partial onset seizures. Pregabalin is also used for fibromyalgia and off-label for generalized anxiety disorders and migraine.
Dosage and administration for Pregabalin
Pregabalin is available in capsules in varying concentrations from 25 to 300 mg under the brand name of Lyrica. The recommended initial dose for neuropathic pain is 50 to 75 mg two to three times daily, the maximum dose being 300 mg daily. Higher doses are used in treating seizures. The dose should be increased and tapered gradually.
Side effects of Pregabalin
Cost and Coupons - Pregabalin
Reviews for Pregabalin
Articles on Pregabalin
Learn more about Pregabalin
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