Pregnane
Pregnane
Pregnane (pronounced: preɪɡˈneɪn) is a parent hydrocarbon for two series of steroids that are formed by the addition of side chains to carbon atoms 20 or 21.
Etymology
The term "Pregnane" is derived from the Latin word 'pregnans', meaning 'pregnant', due to its discovery in the urine of pregnant women.
Structure
Pregnane is a 21-carbon steroid, with a carbon skeleton consisting of three six-membered rings and a five-membered ring. The rings are designated A, B, C, and D from left to right. The two series of steroids formed from pregnane are distinguished by the position of a double bond.
Related Terms
- Pregnane X receptor: A nuclear receptor that in humans is encoded by the NR1I2 (nuclear receptor subfamily 1, group I, member 2) gene.
- Pregnanediol: A metabolite of progesterone. It is excreted in the urine of pregnant women.
- Pregnanes: The family of steroids that includes pregnane, progesterone, and other compounds with similar structures.
Biological Role
Pregnane is a key intermediate in the biosynthesis of many biologically important steroids, including corticosteroids and progestogens. These steroids play crucial roles in a variety of physiological processes, including inflammation, immune response, and the menstrual cycle.
See Also
External links
- Medical encyclopedia article on Pregnane
- Wikipedia's article - Pregnane
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