Primary structure

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Primary Structure

The Primary Structure (pronunciation: /ˈpraɪ.mɛr.i ˈstrʌk.tʃər/) is a term used in Biochemistry to describe the linear sequence of Amino Acids in a Protein or Peptide. The primary structure is determined by covalent bonds, specifically Peptide Bonds, which link the amino acids together in a specific order.

Etymology

The term "Primary Structure" originates from the field of Structural Biology, where it is used to denote the first or 'primary' level of organization in a protein or peptide. The word 'primary' comes from the Latin 'primarius' meaning 'first in order', and 'structure' comes from the Latin 'structura' meaning 'a fitting together, building'.

Related Terms

  • Secondary Structure: The local folding of the polypeptide chain into helices or sheets.
  • Tertiary Structure: The three-dimensional structure of a protein, determined by its side chains.
  • Quaternary Structure: The structure formed by several protein molecules, usually called protein subunits, which function as a single protein complex.
  • Protein Sequencing: A technique to determine the amino acid sequence of a protein, as well as which conformation the protein adopts and the extent to which it is complexed with any non-peptide molecules.
  • Peptide Bond: A chemical bond formed between two molecules when the carboxyl group of one molecule reacts with the amino group of the other molecule.

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