Propanidid

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Propanidid (pronunciation: pro-pan-id-id) is a short-acting intravenous anesthetic agent used in the induction of general anesthesia. It was first introduced in the 1960s by Janssen Pharmaceutica, a Belgium-based pharmaceutical company.

Etymology

The term "Propanidid" is derived from its chemical structure, propyl (three-carbon alkyl group) and amid (referring to its amide group).

Pharmacology

Propanidid is a potent, non-barbiturate, ultra-short-acting, intravenous anesthetic. It is structurally related to other anesthetics like Althesin and Etomidate. It works by enhancing the effect of the neurotransmitter GABA on its receptor, which results in hyperpolarization of the neuron and inhibition of neural activity.

Medical Use

Propanidid was primarily used for the induction of general anesthesia and for short surgical procedures. However, its use was discontinued due to the high incidence of adverse reactions, most notably, severe pain upon injection and a high incidence of anaphylactic reactions.

Side Effects

The most common side effects of Propanidid include pain at the injection site, involuntary muscle movements, and sometimes, severe allergic reactions.

Discontinuation

Propanidid was withdrawn from the market due to the high incidence of adverse reactions. The most serious of these was the high incidence of anaphylactic reactions, which are severe, potentially life-threatening allergic reactions.

See Also

External links

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