Proton pump
Proton Pump
Proton pump (pronunciation: /ˈproʊ.tɒn pʌmp/) is a type of enzyme found in the stomach that helps in the secretion of hydrochloric acid. The term "proton pump" is derived from the Greek word "protos", meaning first, and the English word "pump", referring to the mechanism of action.
Function
Proton pumps are integral membrane proteins that move protons across a cell membrane against a concentration gradient. This process requires energy in the form of adenosine triphosphate (ATP). Proton pumps are primarily found in the parietal cells of the stomach lining, where they play a crucial role in the production of stomach acid.
Clinical Significance
Proton pump inhibitors (PPIs) are a group of drugs that reduce the production of stomach acid by blocking the action of the proton pump. They are commonly used in the treatment of conditions such as gastroesophageal reflux disease (GERD), peptic ulcer disease, and Zollinger-Ellison syndrome.
Related Terms
- Proton pump inhibitor: A type of medication that reduces the production of stomach acid by blocking the action of the proton pump.
- Parietal cell: A type of cell in the stomach lining that contains proton pumps and is responsible for the production of stomach acid.
- Hydrochloric acid: A strong acid produced in the stomach that aids in digestion and kills bacteria.
External links
- Medical encyclopedia article on Proton pump
- Wikipedia's article - Proton pump
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