Reperfusion injury

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Reperfusion Injury

Reperfusion injury (/rɪˈpɜːrfʊʃən ˈɪndʒəri/), also known as ischemia-reperfusion injury or IRI, is a type of tissue damage caused when blood supply returns to the tissue after a period of ischemia or lack of oxygen. The absence of oxygen and nutrients from blood during the ischemic period creates a condition in which the restoration of circulation results in inflammation and oxidative damage through the induction of oxidative stress rather than restoration of normal function.

Etymology

The term "reperfusion injury" is derived from the words "reperfusion" and "injury". "Reperfusion" is a medical term that refers to the restoration of blood flow to an organ or tissue, usually after a period of ischemia. It is derived from the Latin word "reperfusio", which means "to pour back". "Injury" refers to harm or damage, and is derived from the Latin word "injuria", which means "wrong" or "injustice".

Related Terms

  • Ischemia: A condition in which there is insufficient blood flow to the tissues to keep them alive. It is often due to obstruction of the arterial blood supply.
  • Oxidative Stress: An imbalance between the production of free radicals and the ability of the body to counteract or detoxify their harmful effects through neutralization by antioxidants.
  • Inflammation: A localized physical condition in which part of the body becomes reddened, swollen, hot, and often painful, especially as a reaction to injury or infection.
  • Antioxidants: Substances that may protect your cells against the effects of free radicals — molecules produced when your body breaks down food or is exposed to tobacco smoke and radiation.

See Also

External links

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