Resiniferatoxin
Resiniferatoxin (pronunciation: res-uh-nif-er-uh-tox-in) is a naturally occurring chemical found in the resin of the Euphorbia resinifera plant, also known as the Moroccan Spurge. It is an ultrapotent analog of Capsaicin, the active ingredient in chili peppers.
Etymology
The term "Resiniferatoxin" is derived from the plant it is found in, Euphorbia resinifera, and the term "toxin", which refers to a poisonous substance produced within living cells or organisms.
Chemical Structure and Function
Resiniferatoxin has a similar mode of action as Capsaicin, but is significantly more potent. It binds to the Transient Receptor Potential Vanilloid 1 (TRPV1), a protein that responds to heat and inflammation. This binding causes an influx of calcium ions into the cell, leading to the sensation of extreme heat and pain.
Medical Uses
Resiniferatoxin has been studied for its potential use in pain management. Due to its ability to desensitize neurons to pain, it may be used in the treatment of chronic pain conditions such as Osteoarthritis and Neuropathic Pain. However, its extreme potency and potential for causing severe pain upon initial administration have limited its clinical use.
Related Terms
See Also
External links
- Medical encyclopedia article on Resiniferatoxin
- Wikipedia's article - Resiniferatoxin
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