Rottlerin
Rottlerin
Rottlerin (pronunciation: /ˈrɒtlərɪn/), also known as mallotoxin, is a natural polyphenolic compound derived from the Kamala tree (Mallotus philippensis). It was first isolated in 1930 and named after the German botanist, Johann Peter Rottler.
Etymology
The term "Rottlerin" is derived from the name of Johann Peter Rottler, a German botanist who made significant contributions to the field of botany in the late 18th and early 19th centuries. The term "mallotoxin" is derived from the genus name of the Kamala tree, Mallotus, and the Greek word "toxikon", meaning poison.
Usage
Rottlerin has been extensively studied for its potential therapeutic effects in various diseases, including cancer, diabetes, and neurodegenerative diseases. It is known to inhibit the activity of protein kinase C delta type (PKCδ), a protein involved in cell signaling and regulation. However, recent studies suggest that Rottlerin may have multiple targets and mechanisms of action, beyond PKCδ inhibition.
Related Terms
- Polyphenol: A type of chemical that may protect against some common health problems and possibly certain effects of aging.
- Protein kinase C: A family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues.
- Cell signaling: The complex system of communication that governs basic cellular activities and coordinates cell actions.
- Phosphorylation: A post-translational modification of proteins in which a serine, threonine, or tyrosine residue is phosphorylated by a protein kinase by the addition of a covalently bound phosphate group.
External links
- Medical encyclopedia article on Rottlerin
- Wikipedia's article - Rottlerin
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