SH-SY5Y
SH-SY5Y
SH-SY5Y (pronounced as S-H-S-Y-Five-Y) is a human neuroblastoma cell line. It is commonly used in scientific research, particularly in the fields of neuroscience and cell biology.
Etymology
The name SH-SY5Y is an abbreviation derived from the names of the researchers who first isolated the cell line, and the specific clone number. The "SH" stands for Seiichi Hirose, a Japanese researcher who first established the cell line. The "SY" represents the initials of two other researchers, June Biedler and Robert Ross, who further developed the cell line. The "5Y" indicates that this is the fifth subclone of the second successive subcloning.
Description
SH-SY5Y cells are derived from a bone marrow biopsy taken from a four-year-old female with neuroblastoma. These cells are a subclone of the SK-N-SH cell line, which was established from the same biopsy. SH-SY5Y cells are unique in that they can be differentiated into neuron-like cells, making them particularly useful for studying neuronal differentiation and neurodegenerative diseases.
Use in Research
SH-SY5Y cells are widely used in biomedical research. They are particularly useful for studying the nervous system and neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease. They are also used in cancer research, as they are derived from a neuroblastoma, a type of cancer that develops from immature nerve cells.
Related Terms
- Neuroblastoma
- Cell line
- Neuronal differentiation
- Neurodegenerative diseases
- Parkinson's disease
- Alzheimer's disease
- Cancer research
- Nervous system
External links
- Medical encyclopedia article on SH-SY5Y
- Wikipedia's article - SH-SY5Y
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