Sideroblast

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Sideroblast

Sideroblast (pronunciation: /ˈsaɪdərəʊblæst/) is a type of immature red blood cell that has granules of iron accumulated in the mitochondria surrounding the nucleus. The term is derived from the Greek words "sidero-" meaning iron and "-blast" meaning germ or bud.

Types of Sideroblasts

There are two main types of sideroblasts: Ring sideroblast and Non-ring sideroblast. Ring sideroblasts have iron-loaded mitochondria arranged in a ring around the nucleus, while non-ring sideroblasts have iron granules scattered throughout the cell.

Related Conditions

Sideroblasts are associated with several medical conditions, including Sideroblastic anemia, a group of blood disorders characterized by an impaired ability of the bone marrow to produce normal red blood cells. In Myelodysplastic syndrome, a type of cancer in which the bone marrow does not make enough healthy blood cells, sideroblasts may also be present.

Diagnosis

The presence of sideroblasts can be identified through a Bone marrow biopsy and Prussian blue staining, a technique used to detect the presence of iron in biological samples.

Treatment

Treatment for conditions associated with sideroblasts typically involves managing the underlying condition. For example, treatment for sideroblastic anemia may include vitamin B6 therapy, blood transfusions, or in severe cases, a Bone marrow transplant.

See Also

External links

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